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Lucille P Markey Professor of Microbial Pathogenesis and Cell Biology Chair, Microbial Pathogenesis |
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| Galan lab website Phone: (203) 737-2404 (assistant) Lab: (203) 737-2407 Fax: (203) 785-2630 e-mail: jorge.galan@yale.edu |
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Section of Microbial Pathogenesis <Courier Address> |
Central to the pathogenesis of the bacterial pathogen Salmonella typhimurium is its ability to engage the host cell in a two-way biochemical interaction through the function of a dedicated protein secretion system termed type III. This system directs the translocation of several bacterial effector proteins into the host cell resulting in the stimulation of a variety of responses through the activation of small molecular weight GTP-binding proteins of the Rho subfamily. These response are characterized by profuse actin-cytoskeleton rearrangements and nuclear responses leading to bacterial uptake into host cells and the production of pro-inflammatory cytokines. Our laboratory is interested in understanding the mechanisms of the type III protein translocation system, the function of the bacterial effector proteins that are translocated into the host cell as well as the signal transduction pathways
for PDF Fu, Y. and J. E. Galán (1999). A Salmonella typhimurium protein mediates recovery of the host cell architecture after bacterial invasion by antagonizing Rac-1 and CDC42. Nature 401: 293-297.
Zhou, D., M. Mooseker and J. E. Galán (1999). Role of the S. typhimurium actin-binding protein SipA in bacterial internalization. Science 283: 2092-2095.
Kubori, T., Matsushima, Y., Nakamura, D., Uralil, J., Lara-Tejero, M., Sukhan, A., Galán, J.E., and Aizawa, S.-I. (1998). Supramolecular structure of the Salmonella typhimurium type III protein secretion system. Science 280:602-605.
Ruessmann, H., Shams, H., Poblete, F., Fu, Y., Galán, J.E., and Donis, R.O.(1998). Delivery of epitopes by the Salmonella type III secretion system for vaccine development. Science 281:561-568.
