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Professor of Cell Biology Director of M.D./Ph.D. Program Director of Medical Studies |
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Phone: (203) 785-4317 Fax: (203) 785-6936 e-mail: james.jamieson@yale.edu |
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Department of Cell Biology <Courier Address> |
Later work on this topic examined in detail the role of low Mr GTPases in regulated exocytosis. Since regulated exocytosis is accompanied by compensatory endocytosis of excess membrane inserted into the apical plasmalemma, we went on to show an essential role of the actin cytoskeleton in this process and have demonstrated that proteins required for formation of endocytic vesicles (clathrin, adaptors, dynamin etc.) assemble at sites of exocytosis prior to compensatory membrane retrieval.
After more than 30 years carrying out cell biologic research with an impressive and accomplished group of graduate students and postdoctoral fellows, I decided to close my laboratory in 2001 in order to focus my interests on teaching of Cell Biology and Histology to first year medical students. As part of my teaching interest, I also direct MD/PhD Program at Yale University School of Medicine. This allows me to be involved in the education of both medical students and graduate students. The ultimate goal of educating this group of students is to bridge the gap between basic research and clinical medicine.
*Palade, G.E. Intracellular Aspects of the Process of Protein Secretion. Nobel Lecture, December 12, 1974. published in Science, 189:347-358, 1975.
Selected Publications
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Jamieson JD and Friedman SM. (1961) Sodium and potassium shifts associated with peripheral resistance changes in the dog. Circ. Res. 9:996-1004.
Jamieson JD and Palade GE . (1964) Specific granules in atrial muscle cells. J. Cell Biol. 23:151-172.
Jamieson JD and Palade GE. (1967) Intracellular transport of secretory proteins in the pancreatic exocrine cell. I. Role of the peripheral elements of the Golgi complex. J Cell Biol. 34: 577-596.
Jamieson JD and Palade GE. (1967) Intracellular transport of secretory proteins in the pancreatic exocrine cell. II. Transport to condensing vacuoles and zymogen granules. J Cell Biol. 34: 597-615.
Jamieson JD and Palade GE. (1968) Intracellular transport of secretory proteins in the pancreatic exocrine cell. III. Dissociation of intracellular transport from protein synthesis. J Cell Biol. 39: 580-588.
Ingber DE, Madri JA, and Jamieson JD. (1986) Basement membrane as a spatial organizer of polarized epithelia. Exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro. Am. J. Pathol. 122:129-139. 
Gorelick FS, Chang A, and Jamieson JD. (1987) Calcium-calmodulin-stimulated protein kinase in developing pancreas. Am. J. Physiol. 253:G469-G476.
Caplan MJ, Forbush B III, Palade GE, Jamieson JD. (1990) Biosynthesis of the Na,K-ATPase in Madin-Darby canine kidney cells. Activation and cell surface delivery. J Biol Chem. 265: 3528-3534.
Jena BP, Gumkowski F, Fischer von Mollard G, Jahn R, Jamieson JD. (1994) Redistribution of a rab-3 like GTP binding protein from secretory granules to the Golgi complex in pancreatic acinar cells during regulated exocytosis. J Cell Biol. 124: 43-53.
Valentijn JA, Valentijn K, Pastore LM, and Jamieson JD. (2000) Actin coating of secretory granules during regulated exocytosis correlates with the release of rab3D. Proc. Natl. Acad. Sci. USA. 97:1091-1095.
Van Weeren L, de Graff AM, Jamieson JD, Batenburg JJ, and Valentijn JA. (2004) Rab 3D and actin reveal distinct lamellar body subpopulations in alveolar epithelial cells. Am J Respir Cell Mol Biol. 30:288-295.
