| Professor of Cell Biology Director of Graduate Admissions |
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| Novick lab website Phone: (203) 785-5871 Lab: (203) 785-5873/-4316 Fax: (203) 785-7446 e-mail: peter.novick@yale.edu |
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Department of Cell Biology <Courier Address> |
The Exocyst Secretory vesicles are recognized by an octameric complex, termed the exocyst, which resides at specific sites on the plasma membrane. We are studying the interaction of the exocyst with components of the cell polarity establishment machinery and the mechanism of vesicle-exocyst recognition.
Fusion Following vesicle recognition, a SNARE complex, involving integral membrane proteins on both the vesicle and plasma membrane, is formed, catalyzing membrane fusion. We are addressing the mechanism of SNARE complex assembly and function, probing roles for the exocyst and a SNARE-binding protein, Sec1p.
ER Inheritance In collaboration with the Ferro-Novick lab we have initiated a study of ER inheritance in yeast. We are systematically screening the complete library of yeast gene deletions for mutants defective in inheritance of cortical ER. It is already clear that a very similar approach is used to direct the ER into daughter cells as is used in vesicle traffic. Here a different type V myosin, Myo4p, moves the ER into the daughter cell where it is captured by the exocyst complex.
for PDFElkind NB, Walch-Solimena C, Novick P. (2000) The role of the COOH terminus of Sec2p in the transport
of post-Golgi vesicles. J Cell. Biol. 149: 95-110.
Grote E, Carr C, Novick P. (2000) Ordering the final events in yeast exocytosis. J Cell Biol. 151: 439-451.
Grote E, Baba M, Ohsumi Y, Novick P. (2000) Geranygeranylated SNAREs are dominant inhibitors of
membrane fusion. J Cell Biol. 151: 453-465.
Guo W, Tamanoi F, Novick P. (2001) Spatial regulation of the exocyst complex by the Rho1 GTPase.
Nature Cell Biol. 3(4): 353-360.
Ortiz D, Medkova M, Walch-Solimena C, Novick P. (2002) Ypt32 recruits the Sec4p guanine nucleotide
exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeast. J Cell Biol. 157: 1005-1015.
Wiederkehr A, Du Y, Pypaert M, Ferro-Novick S, Novick P. (2003) Sec3p is needed for the spatial regulation
of secretion and for the inheritance of the cortical endoplasmic reticulum. Mol Biol Cell. 14(12): 4770-4782.
