Joerg Bewersdorf, Ph.D.

Assistant Professor of Cell Biology Development and application of novel super resolution microscopy methods.
	Phone: 203-737-5704 Lab: 203-737-5897 Fax: 203-785-7446 e-mail: joerg.bewersdorf at yale.edu	Address: Department of Cell Biology 333 Cedar Street Sterling Hall of Medicine C-425A New Haven, CT 06510

Biographical Sketch

B.S. Physics, University of Freiburg, Germany 1994

M.S.   Physics, Max Planck Institute for Bio Physical Chemistry 1998

Ph.D. Lieca Microsystems, Heidelberg, Germany and Max Planck Institute for Biophysical Chemistry, Göttingen, Germany 2002

Career Appointments:

2002-2005 Postdoctoral fellow, Dept of NanoBiophotonics, Max Planck Institute for
Biophysical Chemistry, Göttingen, Germany
2005-2006 Associate Research Scientist, Jackson Laboratory, University of Maine, Bar
Harbor, ME
2005-2006 Head of Independent Research Group, Development and application of 4Pi-Microscopy and novel super resolution microscopy methods, Jackson Laboratory, University of Maine, Bar Harbor, ME
2007-2009 Adjunct Assistant Professor, Dept of Physics and Astronomy, Jackson Laboratory, University of Maine, Bar Harbor, ME
2007-2009 Research Scientist, Jackson Laboratory, University of Maine, Bar
Harbor, ME

Publications:

J. Bewersdorf, R. Pick and S.W. Hell (1998) “Multifocal Multiphoton Microscopy”, Opt. Lett. 23(9): 655-657

J. Bewersdorf and S.W. Hell (1998) “Picosecond pulsed two-photon imaging with repetition rates of 200 and 400 MHz”, J. Microsc. 191: 28-38

C. Blanca, J. Bewersdorf and S.W. Hell (2001) “Single sharp spot in fluorescence microscopy of two opposing lenses”, Appl. Phys. Lett. 79(15): 2321-2323

N. Martini, J. Bewersdorf and S.W. Hell (2002) “A new high-aperture glycerol immersion objective lens and its application to 3D-fluorescence microscopy”, J. Microsc. 206(2): 146-151.

S.W. Hell, C.M. Blanca and J. Bewersdorf (2002) “Phase determination in interference-based superresolving microscopes through critical frequency analysis”, Opt. Lett. 27(11): 888-890.

C.M. Blanca, J. Bewersdorf and S.W. Hell (2002) “Determination of the unknown phase difference in 4Pi-confocal microscopy through the image intensity”, Opt. Commun. 206: 281-285.

H. Gugel*, J. Bewersdorf*, S. Jakobs, J. Engelhardt, R. Storz and S.W. Hell (2004)
“Cooperative 4Pi excitation and detection yields 7-fold sharper optical sections in live cell microscopy”, Biophys. J. 87: 4146-4152. * equal authorship

J. Bewersdorf, B.T. Bennett, K.L. Knight (2006) “Novel H2AX Chromatin Structures Revealed by 4Pi Microscopy”, Proc. Nat. Acad. Sci. 103: 18137-18142.

R. Medda, S. Jakobs, S.W. Hell, J. Bewersdorf (2006) “Enhanced high-resolution imaging with quantum dots in 4Pi microscopy”, J Struct. Biol. 156: 517–523.

A. Schauss, J. Bewersdorf and S. Jakobs (2006) “Fis1p and Caf4p, but not Mdv1p, are required for a polar localization of Dnm1p clusters on the mitochondrial surface”, J. Cell Sci. 119: 3098-3106.

J. Bewersdorf, R. Schmidt and S.W. Hell (2006) “Comparison of I5M and 4Pi-microscopy”, J. Microsc. 222: 105-117.

J. Bewersdorf, A. Egner, S.W. Hell (2006) “Multifocal Multi-Photon Microscopy” in Handbook of Biological Confocal Microscopy, Pawley, J. (Ed.), 3rd ed., Springer

J. Bewersdorf, A. Egner, S.W. Hell (2006) “4Pi Microscopy” in Handbook of Biological Confocal Microscopy, Pawley, J. (Ed.), 3rd ed., Springer

N. Lue, J. Bewersdorf, M.D. Lessard, K. Badizadegan, R.R. Dasari, M.S. Feld, G. Popescu (2007) “Tissue refractometry using Hilbert phase microscopy”, Opt. Lett. 32(24):3522-3524.

L.B. Caddle, JL Grant, J. Szatkiewicz, J. von Hase, G. Kreth, J. Denegre, B. Shirley, J. Bewersdorf, C. Cremer, A. Arneodo, A. Khalil, K.D. Mills (2007) “Heterologous chromosome territory neighborhoods promote translocation susceptibility in primary lymphocyte”, Chromosome Res. 15:1061-1073.

R. Khanna, Q. Li, J. Bewersdorf, E.F. Stanley (2007) “The presynaptic CaV2.2 channel-transmitter release site core complex”, Eur. J. Neurosci. 26: 547-559.

M. Schwentker, H. Bock, M. Hofmann, S. Jakobs, J. Bewersdorf, C. Eggeling , S.W. Hell (2007) “Wide-field sub-diffraction RESOLFT microscopy using fluorescent protein photoswitching”, Microsc. Res. Techn. 70(3): 269-280.

M.F. Juette, T.J. Gould, M.D. Lessard, M.J. Mlodzianoski, B.S. Nagpure, B.T. Bennett, S.T. Hess, J.Bewersdorf (2008) “Three-dimensional sub-100 nm Resolution Fluorescence Microscopy of Thick Samples”, Nature Methods 5(6):527-529.

L. Plecitá-Hlavatá, M.D. Lessard, J. Šantorováa, J. Bewersdorf, P. Jezek (2008)
“Mitochondrial oxidative phosphorylation and energetic status are reflected by morphology of mitochondrial network in INS-1E and HEP-G2 cells viewed by 4Pi microscopy”, Biophys. Biochim. Acta 1777:834-846.

S.T. Hess, T.J. Gould, M. Gunewardene, J. Bewersdorf, M.D. Mason (2008)
“Ultra-High Resolution Imaging of Biomolecules by Fluorescence Photoactivation Localization Microscopy (FPALM)”, in Methods in Molecular Biology, J.W. Lee (ed.), accepted.

T.J. Gould, J. Bewersdorf, S.T. Hess (2008) “A Quantitative Comparison of the Photophysical Properties of Select Quantum Dots and Organic Fluorophores”, Z. Phys. Chem. 222:833-849.