Agnès Vignery, DDS, Ph.D. Associate Professor, Yale Orthopaedics and Rehabilitation, and Molecular and Cellular Biology Regulation of osteoblast and osteoclast differentiation in bone

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Phone: 203.785.5968 Lab: 203 785 6342 Fax:203 737 2701 e-mail:agnes.vignery@yale.edu

Office Address Orthopaedics and Rehabilitation Yale Physicians Building 800 Howard Avenue P.O. Box 208071 New Haven CT 06520-8071

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Education:

Ph.D., University of Paris, 1975 D.D.S., University of Paris, 1972

Differentiation mechanism of osteoclasts with particular emphasis on the fusion mechanism of macrophages.

Vignery Lab

• Lab website

Recent Publications

Zhang Q, Carlson J, Ke H-Z, Li J, Kim M, Murphy K, Mehta N, Gilligan J, Vignery A. Dramatic increase in cortical thickness induced by femoral marrow ablation followed by a three-month treatment with PTH in rats. J Bone and Mineral Research, in press

Carlson, J, Cui W, Zhang Q, Xu X, Mercant F, Bennett, A, Vignery, A (2009) Role of MKP-1 in osteoclasts and bone homeostasis. Am J Pathol. 2009 Oct;175(4):1564-73. Epub 2009 Sep 17

Carlson, J, Zhang Q, Bennett, A, Vignery, A (2009) Deletion of Mitogen-activated protein kinase phosphatase 1 modifies the response to mechanical bone marrow ablation in a mouse model. Comparative Medicine 59(3),221-226

Zhang, Q, Cuartas, E, Mehta, N, Gilligan, J, Ke, H-Z, Saltzman, WM, Kotas, M, Ma, M, Rajan, S, Chalouni, C, Carlson, J, Vignery, A (2008) Replacement of bone marrow by bone in rat femurs: the bone bioreactor, Tissue Engineering, 14 (2), 237-246

Cui W, Cuartas E, Ke J, Zhang Q, Einarsson H, Sedgwick JD, Li J, VigneryA (2007) CD200 and its receptor, CD200R, modulate bone mass via the differentiation of osteoclasts, Proceedings of the National Academy of Sciences, USA, 104, 14436-14441

Chen E., Grote E., Mohler W, Vignery A. (2007) Cell-Cell fusion, Febs Letters, 581, 2181-2193

Cui W, Zhang Ke J, Zhang Q, Ke H-Z, Chalouni C, Vignery A (2006) The Intracellular Domain of CD44 Promotes the Fusion of Macrophages, Blood, 107, 796-805

Vignery A, Macrophage Fusion: the Making of Osteoclasts and Giant Cells, J Exp Med, 202, 337-340, 2005

Vignery A, Macrophage Fusion: Are Somatic and Cancer Cells Possible Partners?, Trends in Cell Biology, 15, 188-193, 2005

Li H, Cuartas E, Cui W, Choi Y, Crawford DT, Ke HZ, Kobayashi KS, Flavell RA, Vignery A, IRAK-M Is a Central Regulator of Osteoclast Differentiation and Activation, J Exp Med, 201, 1169-1177, 2005

Vignery, A, La fusion des macrophages:partenaires des cellules somatiques et cancereuses?, Medecine/Sciences, 21, 1070-1075, 2005

van Beek EM, Bühring H-J, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel B G, Parkos CA, Sano S-I, Vignery A, Vivier E, Wright M, Zawatzky R, and Barclay AN (2005) A nomenclature for Signal Regulatory Protein Family Member, Journal of Immunology, 175, 7788-7789

Lesclous P, Guez D, Baroukh B, Vignery A, Saffar JL, Histamine participates in the early phase of trabecular bone loss in ovariectomized rats, Bone, 34, 91-99, 2004

Buehler J, Chappuis P, Saffar JL, Tsouderos Y, Vignery A., Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (macaca fascicularis), Bone, 29(2), 176-179, 2001

Han X, Sterling H, Chen Y, Saginario C, Brown EJ, Frazier WA, Lindberg FP, Vignery A, CD47, a ligand for MFR, participates in macrophage multinucleation, Journal of Biological Chemistry, 275(48), 37984-37992, 2000

Millet I, Phillips R, Sherwin RS, Ghosh S, Voll RE, Flavell RA, Vignery A, Rincon M, Inhibition of NF-kappaB activity and enhancement of apoptosis by the neuropeptide calcitonin gene-related peptide, Journal of Biological Chemistry, 275, 15114-15121, 2000

Vignery A, Osteoclasts and giant cells:macrophage-macrophage fusion mechanism, International Journal of Experimental Pathology, 81, 291-304, 2000