Derek K. Toomre PhD

Associate Professor of Cell Biology; Director of the YALE 'CINEMA' Laboratory (Cellular Imaging using New Microscopy Approaches)

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Biochemistry, Biophysics and Structural Biology

Office of Student ResearchSignal TransductionCell Biology: Membrane Traffic; Cytoskeletal DynamicsDiabetes Research CenterSignal Transduction

Research Interests

Cell Biology; Exocytosis; Endocytosis; Membrane Traffic; Tethering; Microscopy; Live Cell Imaging; TIRFM; Single molecule more...


  • M.S., University of California, San Diego, 1992
  • Ph.D., University of California, San Diego, 1996

Selected Publications

  • Zoncu R, Perera RM, Balkin DM, Pirruccello M, Toomre D, De Camilli P. A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes. Cell. 2009 Mar 20;136(6):1110-21. PubMed PMID: 19303853; PubMed Central PMCID: PMC2705806.
  • Perera RM, Zoncu R, Lucast L, De Camilli P, Toomre D. Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19332-7. Epub 2006 Dec 8.
  • Sebastian R, Diaz ME, Ayala G, Letinic K, Moncho-Bogani J, Toomre D. Spatio-temporal analysis of constitutive exocytosis in epithelial cells. IEEE/ACM Trans Comput Biol Bioinform. 2006 Jan-Mar;3(1):17-32.



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