James E Rothman, PhD

Fergus F. Wallace Professor of Cell Biology and Professor of Chemistry; Chairman, Department of Cell Biology; Director, Nanobiology Institute

Research Interests

Research Organizations

Cell Biology: Membrane Traffic

Fellowship Training

Research Summary

We take an interdisciplinary approach, which includes cell-free biochemistry, single molecule biophysics, and super-resolution optical imaging of single events/single molecules in the cell and in cell-free formats. The overall goal is to understand transport pathways form structural mechanism to cellular physiology. We have a strong interest in new lab members who bring backgrounds in protein biochemistry, organic chemistry, biophysics, and bio-engineering.

Extensive Research Description

  1. The biophysical mechanisms of membrane fusion.
  2. Regulation of vesicle fusion in synaptic transmission.
  3. Structural and functional organization of the Golgi apparatus.

Selected Publications

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Contact Info

James E Rothman, PhD
Lab Location
Rothman LaboratorySterling Hall of Medicine, C-Wing
333 Cedar Street, Ste SHM C-434

New Haven, CT 06510
Mailing Address
Chairman's Office333 Cedar Street
New Haven, CT 06520-8002

Rothman Lab