Malaiyalam Mariappan

Assistant Professor of Cell Biology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Biochemistry, Biophysics and Structural Biology

Office of Student ResearchCell Biology

Research Interests

Unfolded Protein Response (UPR); Endoplasmic Reticulum; Protein Translocation and Insertion; ER stress response; Misfolded Proteins; Protein Quality Control more...


  • M.Sc., University of Madras, India, 2001
  • Ph.D., University of Goettingen, Germany, 2005

Selected Publications

  • Plumb, P., Zhang, Z. R., Appathurai, S., and Mariappan. M#. A functional link between the co-translational protein translocation pathway and the UPR (eLife, in press) # Corresponding author
  • *Mariappan, M., *Mateja, A., Dobosz, M., Bove, E., Hegde, R. S., and Keenan, R. J. (2011) The mechanisms of membrane associated steps in tail-anchored protein insertion. Nature 477, 61-66.
  • Hessa, T., Sharma, A., Mariappan, M., Eshleman, H. D., Gutierrez, E., and Hegde, R. S. (2011) Protein targeting and degradation pathways are coupled for elimination of mislocalized proteins. Nature 475, 393-397.



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