Michael J Caplan PhD, MD

C. N. H. Long Professor of Cellular and Molecular Physiology and Professor of Cell Biology; Chair, Cellular and Molecular Physiology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Molecular Medicine, Pharmacology, and Physiology

LCME Faculty SubcommitteeCell Biology: Membrane Traffic | Cellular & Molecular Physiology: Membrane Proteins - Pumps and Transporters; Membrane Protein Sorting and Trafficking; Epithelial Transport of Ions and Solutes; Organ Physiology; Physiology of Human Disease; Graduate Program in Cellular and Molecular PhysiologyCenter for Polycystic Kidney Disease Research

Research Interests

Ion pumps in polarized epithelia; Sorting and function more...


  • Ph.D., Yale University, 1987
  • M.D., Yale University, 1987

Selected Publications

  • Grimm DH, Cai Y, Chauvet V, Rajendran V, Zeltner R, Geng L, Avner ED, Sweeney W, Somlo S, Caplan MJ. Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells. J Biol Chem, 278:36786-36793, 2003.
  • Duffield A, Kamsteeg EJ, Brown AN, Pagel P, Caplan MJ. The tetraspanin CD63 enhances the internalization of the H,K-ATPase β-subunit. Proc Nat Acad Sci USA, 100:15560-15565, 2003.
  • Chauvet V, et al. Mechanical stimuli induce the cleavage and nuclear translocation of the polycystin-1 C-terminus. J Clin Invest, 114:1433-1443, 2004.



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