Structural biology

Macromolecular crystallography, in combination with other biophysical and biochemical techniques, is the most powerful tool currently available for obtaining the high resolution information necessary to understand the details of the macromolecular interactions governing cell life. Shortly after research groups within the department identify which interactions are important, efforts to visualize critical macromolecular complexes begin.

One group of current projects focuses on understanding protein-RNA interactions, as required for RNA processing; another aims to understand the last steps of exocytosis at the atomic level.

Investigators in this research area

Peter Novick
Karin Reinisch
Elisabetta Ullu
Sandra Wolin